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Diseases

Genetic and Rare Diseases Information Center (GARD)

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PANDAS


Other Names for this Disease
  • Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections
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Treatment

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How might PANDAS be treated?

The treatment of PANDAS is symptomatic. Children who are diagnosed with a group A streptococcal infection are typically treated with antibiotics whether or not they develop symptoms of PANDAS. Obsessive-compulsive disorders are usually managed with medications (i.e. SSRI medications such as fluoxetine, fluvoxamine, sertaline, or paroxetine) and cognitive behavioral therapy. Tic disorders are often treated with a variety of medications, as well.[1][2]

Some researchers suspect that therapies such as plasmapheresis and/or intravenous immunoglobulin (IVIG), which are often used to treat autoimmune disorders, may be a treatment option for children with PANDAS. Plasmapheresis is a procedure that removes antibodies from the blood. IVIG can sometimes be used to alter the function or production of abnormal antibodies. Although some studies have demonstrated that both of these therapies are effective for the treatment of severe, strep triggered OCD and tics, a number of the children in these studies experienced severe side-effects. Thus, these treatments are often reserved for severely affected children who do not respond to other therapies.[1][2]
Last updated: 3/31/2015

References
  1. Michael E Pichichero, MD. PANDAS: Pediatric autoimmune neuropsychiatric disorder associated with group A streptococci. UptoDate. July 2013; Accessed 3/30/2015.
  2. Information About PANDAS. National Institute of Mental Health. Accessed 3/30/2015.


Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied PANDAS. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.