Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Paroxysmal nocturnal hemoglobinuria


Other Names for this Disease

  • Marchiafava-Micheli disease
  • PNH
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

Why does it appear that hemolysis occurs mostly at night?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Why does it appear that hemolysis mostly occurs at night?

The term "nocturnal" refers to the belief that hemolysis is triggered by acidosis during sleep. However, this observation was later disproved. In individuals with paroxysmal nocturnal hemoglobinuria, hemolysis has been shown to occur throughout the day, but the urine concentrated overnight produces the dramatic change in color.[1] It is most noticeable in the morning, upon passing urine that has accumulated in the bladder during the night.[2]
Last updated: 1/15/2011

References
Other Names for this Disease
  • Marchiafava-Micheli disease
  • PNH
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.