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Paroxysmal nocturnal hemoglobinuria


Other Names for this Disease

  • Marchiafava-Micheli disease
  • PNH
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired disorder that leads to the premature death and impaired production of blood cells. It can occur at any age, but is usually diagnosed in young adulthood. People with PNH have recurring episodes of symptoms due to hemolysis, which may be triggered by stresses on the body such as infections or physical exertion. This results in a deficiency of various types of blood cells and can cause signs and symptoms such as fatigue, weakness, abnormally pale skin (pallor), shortness of breath, and an increased heart rate. People with PNH may also be prone to infections and abnormal blood clotting (thrombosis) or hemorrhage, and are at increased risk of developing leukemia. It is caused by acquired, rather than inherited, mutations in the PIGA gene; the condition is not passed down to children of affected individuals. Sometimes, people who have been treated for aplastic anemia may develop PNH.[1] The treatment of PNH is largely based on symptoms; stem cell transplantation is typically reserved for severe cases of PNH with aplastic anemia or those whose develop leukemia.[2]
Last updated: 1/15/2011

References

  1. Paroxysmal nocturnal hemoglobinuria. Genetics Home Reference. May 2007; http://ghr.nlm.nih.gov/condition/paroxysmal-nocturnal-hemoglobinuria. Accessed 1/15/2011.
  2. Emmanuel C Besa and Ulrich Woermann. Paroxysmal Nocturnal Hemoglobinuria. eMedicine. March 27, 2009; http://emedicine.medscape.com/article/207468-overview. Accessed 1/15/2011.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Paroxysmal nocturnal hemoglobinuria. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers. 
  • The National Heart, Lung, and Blood Institute (NHLBI) can provide information on this topic. You can reach them by calling 301-592-8573 or by E-mail at nhlbiinfo@nhlbi.nih.gov
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Paroxysmal nocturnal hemoglobinuria. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Marchiafava-Micheli disease
  • PNH
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.