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Genetic and Rare Diseases Information Center (GARD)

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Peeling skin syndrome

Other Names for this Disease
  • Deciduous skin
  • Familial continuous skin peeling
  • Keratolysis exfoliativa congenita
  • Peeling skin syndrome, acral type (subtype)
  • Peeling skin syndrome, inflammatory type B (subtype)
More Names
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Your Question

Are there any cures for this disorder? I read somewhere that gene therapy may be a potential treatment. If not, are there any topical treatments that can ease my symptoms?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

How might peeling skin syndrome be treated?

There is currently no cure for peeling skin syndrome and unfortunately, no effective treatment has been reported. Topical emollients (skin softening ointments) may help; plain petroleum jelly has been used by some individuals.[1][2] Keratolytic agents might speed up shedding and improve appearance. Treatments such as methotrexate, UVB phototherapy, isotretinoin, and oral corticosteroid therapy have been found to be ineffective in past studies.[1]
Last updated: 6/13/2011

Is gene therapy a potential treatment for peeling skin syndrome?

Gene therapy is currently available only in a research setting, and it is not available for most disorders. The U.S. Food and Drug Administration (FDA) has not yet approved any gene therapy products for sale in the United States. However, hundreds of research studies (clinical trials) are under way to test gene therapy as a treatment for genetic conditions, cancer, and HIV/AIDS., a service of the National Institutes of Health, provides easy access to information on clinical trials. You can search for specific trials or browse by condition or trial sponsor. You may wish to refer to a list of gene therapy trials that are accepting (or will accept) participants.[3]
Last updated: 6/13/2011