Polycystic kidney disease
* Not a rare disease
Other Names for this Disease
- Polycystic kidneys
What are the signs and symptoms of polycystic kidney disease?
The two major forms of polycystic kidney disease are distinguished by the usual age of onset and their pattern of inheritance:
(1) Autosomal dominant polycystic kidney disease (ADPKD) is the most common form that usually causes symptoms between the ages of 30 and 40; but they can begin earlier, even in childhood. ADPKD can be further divided into type 1 and type 2, depending on the underlying genetic cause.
(2) Autosomal recessive polycystic kidney disease (ARPKD) is a rare form that usually causes symptoms in infancy and early childhood and is often lethal early in life. Some people with ARPKD do not develop symptoms until later in childhood or even adulthood.
Frequent complications of polycystic kidney disease include dangerously high blood pressure (hypertension), severe pain in the back or sides, blood in the urine (hematuria), recurrent urinary tract infections, kidney stones, and heart valve abnormalities. People with this condition also have an increased risk an aortic aneurysm in the brain (an abnormal bulging of the large blood vessel at the base of the brain). Aneurysms can be life-threatening if they tear or rupture.
- Polycystic kidney disease. Genetics Home Reference. 2006; http://ghr.nlm.nih.gov/condition/polycystic-kidney-disease. Accessed 12/8/2011.
- Polycystic Kidney Disease. National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC). 2010; http://kidney.niddk.nih.gov/kudiseases/pubs/polycystic/. Accessed 12/8/2011.