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Other Names for this Disease
- Polycythemia rubra vera
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deep vein thrombosis (DVT), a type of blood clot that occurs in the deep veins of the arms or legs. If a DVT travels through the bloodstream and lodges in the lungs, it can cause a life-threatening clot known as a pulmonary embolism (PE). Affected individuals also have an increased risk of heart attack and stroke caused by blood clots in the heart and brain. Polycythemia vera is associated with mutations in the JAK2 and TET2 genes. Most cases are not inherited, as the condition is associated with genetic changes that are somatic, which means they are acquired during a person's lifetime and are present only in certain cells.Polycythemia vera is a condition characterized by an increased number of red blood cells within the bloodstream. Affected individuals may also have excess white blood cells and platelets. These extra cells cause the blood to be thicker than normal. As a result, abnormal blood clots are more likely to form and block the flow of blood through arteries and veins. Individuals with polycythemia vera have an increased risk of
Last updated: 9/21/2010
- Polycythemia vera. Genetics Home Reference (GHR). 2010; http://ghr.nlm.nih.gov/condition/polycythemia-vera. Accessed 9/21/2010.
- Genetics Home Reference (GHR) contains information on Polycythemia vera. This website is maintained by the National Library of Medicine.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic. Click on the link to view this information.
- The Merck Manuals Online Medical Library provides information on this condition. Click on the link to view the information.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
- The CMPD Education Foundation provides online information on myeloproliferative disorders (MPD). Click on the link to view the resource.
- eMedicine has 2 articles on this topic from the perspective of Pediatrics: General Medicine and Hematology. You may need to register to view the information online, but registration is free. Click on the links above to view the articles from this medical reference Web site.
In Depth Information
- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Polycythemia vera. Click on the link to go to OMIM and review these resources.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Polycythemia vera. Click on the link to view a sample search on this topic.