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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Primary biliary cirrhosis


Other Names for this Disease

  • Familial primary biliary cirrhosis
  • PBC
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

Management Guidelines

  • The National Guideline Clearinghouse (NGC) is a public resource for evidence-based clinical practice guidelines. The NGC was originally created by the Agency for Healthcare Research and Quality (AHRQ) in partnership with the American Medical Association and the American Association of Health Plans.

Clinical Trials & Research for this Disease

  • The Centers for Mendelian Genomics program is working to discover the causes of rare genetic disorders. For more information about applying to the research study, please visit their website.
  • The Childhood Liver Disease Research and Education Network (ChiLDREN) is a team of doctors, nurses, research coordinators, and research labs throughout the U.S., working together to improve the lives of people with rare liver diseases through research. Current studies are enrolling people with Alagille syndrome, alpha one-antitrypsin deficiency, bile acid synthesis defects, biliary atresia, cystic fibrosis liver disease, idiopathic neonatal hepatitis, mitochondrial hepatopathies, and progressive familial intrahepatic cholestasis. Click on the link above to learn more.

    Visit the following link to find the participating research center nearest you.
    http://childrennetwork.org/centers.html

  • ClinicalTrials.gov lists trials that are studying or have studied Primary biliary cirrhosis. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
  • Orphanet lists clinical trials, research studies, and patient registries enrolling people with this condition. Click on Orphanet to view the list.
  • The Research Portfolio Online Reporting Tool (RePORT) provides access to reports, data, and analyses of research activities at the National Institutes of Health (NIH), including information on NIH expenditures and the results of NIH-supported research. Although these projects may not conduct studies on humans, you may want to contact the investigators to learn more. To search for studies, enter the disease name in the "Text Search" box. Then click "Submit Query".

Medical Products

The medication(s) listed in the table(s) below have been approved by the Food and Drug Administration (FDA) for treatment of this condition. The FDA Office of Orphan Products Development designates "orphan products" for those that treat rare diseases affecting fewer than 200,000 Americans. The table(s) below may not be an exhaustive list of drugs or products used to treat this condition. There may be other products available that are not considered orphan products. To search for all FDA approved drugs, visit Drugs@FDA. You can find orphan products used to treat other conditions by searching the Orphan Drug Product Designation database.


Generic Name Ursodiol
Trade Name
(Manufacturer Name)
Actigall®
(Watson Pharmaceuticals)
Indication
The FDA has approved this product to be used in this manner.
Treatment of patients with primary biliary cirrhosis.
More Information about this product Drug Information Portal
Medline Plus Health Information

Generic Name Ursodiol
Trade Name
(Manufacturer Name)
Ursodiol
(Lannett Company, Inc.)
Indication
The FDA has approved this product to be used in this manner.
Treatment of patients with primary biliary cirrhosis.
More Information about this product Drug Information Portal
Medline Plus Health Information

Other Names for this Disease
  • Familial primary biliary cirrhosis
  • PBC
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.