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Genetic and Rare Diseases Information Center (GARD)

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Progressive multifocal leukoencephalopathy

Other Names for this Disease
  • Leukoencephalopathy, progressive multifocal
  • PML
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What is the prognosis for individuals diagnosed with progressive multifocal leukoencephalopathy (PML)?

The mortality rates for those with HIV-PML have fallen dramatically from approximately 90 percent to around 50 percent according to most reports. For non-AIDS individuals with PML, the prognosis remains grim; the disease usually lasts for months and 80 percent die within the first 6 months, although spontaneous improvement has been reported.  Those who survive PML can be left with severe neurological disabilities.[1]
Last updated: 3/3/2011

  1. NINDS Progressive Multifocal Leukoencephalopathy Information Page. National Institute of Neurological Disorders and Stroke (NINDS). 2010; Accessed 3/3/2011.