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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Progressive supranuclear palsy


Other Names for this Disease
  • Familial progressive supranuclear palsy (type)
  • PSP
  • Steele-Richardson-Olszewski Syndrome
  • Supranuclear palsy, progressive
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Overview


Progressive supranuclear palsy is a movement disorder caused by damage to certain nerve cells in the brain. It affects brain cells that control the movement of the eyes. This leads to serious and permanent problems with balance and the way affected individuals walk. It usually occurs in middle-aged or elderly people. Symptoms are very different in each person, but may include personality changes, speech, vision and swallowing problems. Doctors sometimes confuse progressive supranuclear palsy with Parkinson's disease or Alzheimer's disease. Progressive supranuclear palsy has no cure and no effective treatments.[1] In most cases, the genetic cause of this condition is unknown. Rarely, the disease results from mutations in the MAPT gene.[2] 
Last updated: 8/18/2011

References

  1. Progressive supranuclear palsy. MedlinePlus Medical Encyclopedia. May 2010; http://www.nlm.nih.gov/medlineplus/ency/article/000767.htm. Accessed 8/18/2011.
  2. Progressive supranuclear palsy. Genetics Home Reference. March 2011; http://ghr.nlm.nih.gov/condition/progressive-supranuclear-palsy. Accessed 9/7/2012.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Progressive supranuclear palsy. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Progressive supranuclear palsy. Click on the link to view a sample search on this topic.

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