Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Pseudohypoparathyroidism type 1A

Other Names for this Disease
  • Albright hereditary osteodystrophy with multiple hormone resistance
  • PHP1A
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


Pseudohypoparathyroidism type 1A is a genetic disorder that resembles hypoparathyroidism (lowered levels of parathyroid hormone), but is caused by a lack of response to parathyroid hormone rather than having too little of the hormone itself. This condition is very similar to hypoparathyroidism, with low calcium levels and high phosphate levels in the blood. This results in the characteristic symptoms which are generally first seen in childhood. There are two different types of pseudohypoparathyroidism. Type 1A is caused by a mutation in the GNAS gene and is inherited in an autosomal dominant manner. This defect also causes short stature, a round face, and short hand bones, which is referred to as Albright's hereditary osteodystrophy.[1][2]
Last updated: 10/7/2011


  1. Topiwala S. Pseudohypoparathyroidism. MedlinePlus. July 2012; Accessed 10/17/2012.
  2. Pseudohypoparathyroidism type 1A. Online Mendelian Inheritance of Man (OMIM). June 2010; Accessed 10/7/2011.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

Please contact us with your questions about Pseudohypoparathyroidism type 1A. We will answer your question and update these pages with new resources and information.

Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Pseudohypoparathyroidism type 1A. Click on the link to view a sample search on this topic.

Selected Full-Text Journal Articles