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Genetic and Rare Diseases Information Center (GARD)

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Rosai-Dorfman disease

Other Names for this Disease
  • RDD
  • Rosaï-Dorfman disease
  • SHML
  • Sinus histiocytosis with massive lymphadenopathy
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What causes Rosai-Dorfman disease?

The exact cause of Rosai-Dorfman disease is unknown.[1][2] Possible causes include altered immune responses and infections by agents such as varicella-zoster and other herpetic viruses; Epstein-Barr; cytomegalovirus; Brucella; and Klebsiella.[1]
Last updated: 7/22/2013

  1. Gomes Pinto DC, de Aguiar Vidigal T, de Castro B, dos Dantos BH, de Sousa NJA. Rosai-Dorfman disease in the differential diagnosis of cervical lymphadenopathy. Rev. Bras. Otorrinolaringol. 2008; Accessed 7/22/2013.
  2. Rosai J. Rosai-Dorfman Disease. National Organization for Rare Disorders (NORD). 2011; Accessed 7/22/2013.