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Genetic and Rare Diseases Information Center (GARD)

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Autoimmune polyglandular syndrome type 2


Other Names for this Disease

  • APS2
  • Autoimmune polyendocrine syndrome type 2
  • Diabetes mellitus, Addison's disease, myxedema
  • Multiple endocrine deficiency syndrome, type 2
  • PGA 2
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Overview

Autoimmune polyglandular syndrome type 2 is an autoimmune disorder that affects many hormone-producing (endocrine) glands.[1] This condition is characterized by the presence of Addison's disease along with autoimmune thyroid disease and/or type 1 diabetes.[1] Affected individuals may also have problems with other endocrine glands. Autoimmune polyglandular syndrome type 2 is diagnosed in adulthood, typically around age 30.[2] This condition occurs more often in women than men, and treatment primarily involves hormone replacement therapy.[1] The cause of autoimmune polyglandular syndrome type 2 is unknown, although it may involve a combination of genetic and environmental factors.[1]
Last updated: 3/24/2010

References

  1. Sivarajah S, Fan CY, Akinsoto OPA. Polyglandular Autoimmune Syndrome, Type II. eMedicine Journal. October 2, 2008; http://emedicine.medscape.com/article/124287-overview. Accessed 3/24/2010.
  2. Polyglandular Deficiency Syndromes. Merck Manual for Healthcare Professionals. November 2009; http://www.merck.com/mmpe/sec12/ch154/ch154a.html. Accessed 3/24/2010.
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  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Autoimmune polyglandular syndrome type 2. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • APS2
  • Autoimmune polyendocrine syndrome type 2
  • Diabetes mellitus, Addison's disease, myxedema
  • Multiple endocrine deficiency syndrome, type 2
  • PGA 2
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.