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Autoimmune polyglandular syndrome type 2

Other Names for this Disease
  • APS2
  • Autoimmune polyendocrine syndrome type 2
  • Diabetes mellitus, Addison's disease, myxedema
  • Multiple endocrine deficiency syndrome, type 2
  • PGA 2
More Names
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Autoimmune polyglandular syndrome type 2 is an autoimmune disorder that affects many hormone-producing (endocrine) glands.[1] This condition is characterized by the presence of Addison's disease along with autoimmune thyroid disease and/or type 1 diabetes.[1] Affected individuals may also have problems with other endocrine glands. Autoimmune polyglandular syndrome type 2 is diagnosed in adulthood, typically around age 30.[2] This condition occurs more often in women than men, and treatment primarily involves hormone replacement therapy.[1] The cause of autoimmune polyglandular syndrome type 2 is unknown, although it may involve a combination of genetic and environmental factors.[1]
Last updated: 3/24/2010


  1. Sivarajah S, Fan CY, Akinsoto OPA. Polyglandular Autoimmune Syndrome, Type II. eMedicine Journal. October 2, 2008; Accessed 3/24/2010.
  2. Polyglandular Deficiency Syndromes. Merck Manual for Healthcare Professionals. November 2009; Accessed 3/24/2010.
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