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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Scleromyxedema


Other Names for this Disease

  • Arndt-Gottron disease
  • Generalized lichenoid papular eruption
  • Generalized papular and sclerodermoid
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

My husband was 43 years old when he died from complications associated with scleromyxedema. We have 2 daughters and one son. Is it hereditary, and should they be tested for the disease?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What causes scleromyxedema?

The underlying cause of scleromyxedema remains unknown.[1][2] In a few cases, it has been reported in association with cancers of the bone marrow such as myeloma, lymphoma and leukemia.[3]
Last updated: 4/18/2014

Is scleromyxedema inherited?

The underlying cause of scleromyxedema remains unknown. We are not aware of any familial cases of the disorder, and to our knowledge, there has not been any evidence that scleromyxedema is inherited.
Last updated: 4/18/2014

Is genetic testing available for scleromyxedema?

No. The underlying cause of scleromyxedema is not known, and no specific genes have been found to cause the disorder.
Last updated: 4/18/2014

References
  • Koronowska SK, Osmola-Mankowska A, Jakubowicz O, Zaba R. Scleromyxedema: a rare disorder and its treatment difficulties. Postepy Dermatol Alergol. April, 2013; 30(2):122-126. Accessed 4/18/2014.
  • Franco Rongioletti. Scleromyxedema. UpToDate. Waltham, MA: UpToDate; April, 2014; Accessed 4/18/2014.
  • Eugene Tan. Lichen myxoedematosus. DermNet NZ. 2008; http://dermnetnz.org/immune/scleromyxoedema.html. Accessed 4/18/2014.
Other Names for this Disease
  • Arndt-Gottron disease
  • Generalized lichenoid papular eruption
  • Generalized papular and sclerodermoid
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.