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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Scleromyxedema


Other Names for this Disease
  • Arndt-Gottron disease
  • Generalized lichenoid papular eruption
  • Generalized papular and sclerodermoid
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Overview


Scleromyxedema is a rare, severe skin disorder. Signs and symptoms include abnormal accumulation of mucin in the skin (mucinosis), causing papular and sclerodermoid bumps; increased production of fibroblasts (connective tissue cells) in the absence of a thyroid disorder; and monoclonal gammopathy (abnormal proteins in the blood). It often involves internal organs and may affect various body systems.[1][2] The cause of scleromyxedema is not known. Management may involve the use of intravenous immunoglobulin (IVIG) and/or plasmapheresis, but no standard treatment exists.[2]
Last updated: 4/18/2014

References

  1. Franco Rongioletti. Scleromyxedema. UpToDate. Waltham, MA: UpToDate; April, 2014; Accessed 4/18/2014.
  2. Koronowska SK, Osmola-Mankowska A, Jakubowicz O, Zaba R. Scleromyxedema: a rare disorder and its treatment difficulties. Postepy Dermatol Alergol. April, 2013; 30(2):122-126. Accessed 4/18/2014.
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Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
  • The Doctor's Doctor provides information about scleromyxedema. Click on the link to view this information.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Scleromyxedema. Click on the link to view a sample search on this topic.
  • UpToDate has an article on Scleromyxedema. Click on UpToDate to view the page.