- Sézary lymphoma
- Sézary syndrome
- Sezary's lymphoma
Your QuestionCan Sezary syndrome be cured?
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- Topical corticosteroids.
- Topical chemotherapy with mechlorethamine (nitrogen mustard) or carmustine (BCNU).
- Psoralen and ultraviolet A radiation (PUVA).
- Ultraviolet B radiation (UVB).
- Total-skin electron-beam radiation (TSEB).
- Radiation of symptomatic skin lesions.
- Interferon-alpha alone or in combination with topical therapy.
- Single-agent and multiagent chemotherapy.
- Bexarotene (topical gel or oral); retinoids.
- Denileukin diftitox (recombinant fusion protein of diptheria toxin fragments and interleukin-2 sequences).
- Combined modality treatment.
These types of treatments are aimed at producing remissions and improving symptoms. Treatment, therefore, is considered palliative for most patients. Survival in excess of 8 years is common. Patients with Sezary syndrome may benefit from participation in clinical trials evaluating new approaches to treatment.
More details about treatment of Sezary syndrome can be accessed by clicking here.
Orphanet lists clinical trials, research studies, and patient registries enrolling people with this condition. Click on Orphanet to view the list.
The Research Portfolio Online Reporting Tool (RePORT) provides access to reports, data, and analyses of research activities at the National Institutes of Health (NIH), including information on NIH expenditures and the results of NIH-supported research. Although these projects may not conduct studies on humans, you may want to contact the investigators to learn more. To search for studies, click on the link and enter the disease name in the 'Terms Search' box. Then click 'Submit Query'.
- Mycosis Fungoides and the Sézary Syndrome Treatment (PDQ®) . National Cancer Institute. 1/29/2010; http://www.cancer.gov/cancertopics/pdq/treatment/mycosisfungoides/Patient. Accessed 2/8/2011.
- Mycosis Fungoides and Sezary Syndrome Treatment (PDQ) - Treatment Option Overview. National Cancer Institute (NCI). 2010; http://www.cancer.gov/cancertopics/pdq/treatment/mycosisfungoides/HealthProfessional/page4. Accessed 2/8/2011.