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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Sezary syndrome


Other Names for this Disease

  • Sézary syndrome
  • Sezary's lymphoma
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Cause

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What causes Sezary syndrome?

Although several possible underlying causes of Sezary syndrome have been proposed, the exact cause remains unknown. Current research suggests that abnormalities of DNA are the underlying basis for cells becoming malignant (cancerous) in cutaneous T-cell lymphomas and other cancers. Although in some cases a predisposition to cancer may be inherited, most cancers result from abnormal genetic changes that occur spontaneously, possibly due to various environmental factors.[1] Some researchers have suggested that skin-associated microbes such as  Staphylococcus aureus and Chlamydia spp may play a role in antigen stimulation of T-cells, but definitive data has been very limited. Others have made associations between Sezary syndrome and cytomegalovirus and Epstein-Barr virus. More research regarding the potential causes of Sezary syndrome is needed and is currently under way.[2]
Last updated: 4/30/2012

References
  1. Cutaneous T-Cell Lymphomas. NORD. January 3, 2007; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/1124/viewAbstract. Accessed 4/30/2012.
  2. Hwang ST, Janik JE, Jaffe ES, Wilson WH. Mycosis fungoides and S├ęzary syndrome. Lancet. March 15, 2008; 371(9616):945-957.


Other Names for this Disease
  • Sézary syndrome
  • Sezary's lymphoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.