Spinal muscular atrophy
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Your QuestionAre there any other diseases or conditions that have similar symptoms to SMA, or mimic the symptoms of SMA?
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The main characteristics of spinal muscular atrophies (SMA) include progressive muscle weakness and poor muscle tone (hypotonia), which may be present with a variety of conditions. (For a more detailed explanation of the signs and symptoms of SMA click here.) Some symptoms of the following conditions can be similar to the characteristic features of SMA, although they typically have additional features which are not present in SMA. Some of them may be considered depending on the age of onset of signs and symptoms as well as other features that are present in affected individuals.
- Prader-Willi syndrome and other chromosome abnormalities
- Pompe disease
- Congenital myasthenia
- Congenital myopathies (such as nemaline myopathy, central core disease, and myotubular myopathy)
- Myotonic dystrophy
- Congenital muscular dystrophy
- Duchenne muscular dystrophy
- Becker muscular dystrophy
- Kennedy's disease
- Amyotrophic lateral sclerosis
- Zellweger syndrome spectrum
- Peripheral neuropathies, including Guillain-Barré syndrome
- Central nervous system abnormalities
- trauma to the spinal cord
Last updated: 11/28/2011
- Thomas W Prior, Barry S Russman. Spinal Muscular Atrophy. GeneReviews. January 27, 2011; http://www.ncbi.nlm.nih.gov/books/NBK1352/. Accessed 11/28/2011.
- Spinal Muscular Atrophy. NORD. November 25, 2008; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/1135/viewAbstract. Accessed 11/28/2011.