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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Susac syndrome


Other Names for this Disease
  • Retinocochleocerebral vasculopathy
  • SICRET (small infarction of cochlear, retinal, and encephalic tissue) syndrome
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Cause


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What causes Susac syndrome?

The cause of Susac syndrome is still unknown. But it is suspected to be an autoimmune endotheliopathy, a disorder in which the body's immune system mistakenly attacks the lining (endothelium) of the walls of the very tiny blood vessels that supply blood to the brain, retinas, and inner ears.[1]

The symptoms of this condition result from damage to these very small blood vessels, which in turn results in decreased or impaired blood flow. Impaired blood flow to the brain, retinas and inner ears (microinfarcts) results in damage to the tissue or organs in these areas.[2]
Last updated: 4/25/2011

References
  1. Susac's Syndrome. National Organization for Rare Disorders (NORD). December 2010; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Susac%27s%20Syndrome. Accessed 4/25/2011.
  2. Rennebohm, Robert; Susac, John. Journal of Neurological Sciences. February 26,2007; http://www.ncbi.nlm.nih.gov/pubmed/17324441. Accessed 1/1/1900.