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Genetic and Rare Diseases Information Center (GARD)

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Synovial sarcoma

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Tests & Diagnosis

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How is synovial sarcoma diagnosed?

A doctor may use the following procedures and tests to diagnose synovial sarcoma:[1]
  • Biopsy: Tissue is removed for examination under a microscope.
  • Immunohistochemical analysis: Tumor tissue is tested for certain antigen and antibody interactions common to synovial sarcoma.
  • Ultrastructural findings: The tissue is examined using an ultramicroscope and electron microscope.
  • Genetic testing: Tissue is tested for a specific chromosome abnormality common to synovial sarcoma. The characteristic chromosome translocation t(X;18)(p11.2;q11.2) is present in nearly all synovial sarcomas, providing strong evidence for the diagnosis of this tumor.[2]
Last updated: 7/11/2011

  1. Synovial Sarcoma: Questions and Answers. National Cancer Institute (NCI). 2005; Accessed 7/11/2011.
  2. Ruggiero A. Synovialsarcoma. Orphanet. March 2004; Accessed 7/11/2011.