Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Transposition of the great arteries


Other Names for this Disease

  • Dextro-looped transposition of the great arteries
  • DTGA
  • TGA
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Transposition of the great arteries (TGA) is a type of congenital heart defect in which there is a reversal of the normal connections of the aorta and the pulmonary artery with the heart. The aorta and pulmonary artery are reversed, which causes oxygen-poor blood to be circulated to the body and oxygen-rich blood to be circulated between the lungs and the heart, rather than to the body. Symptoms are apparent at birth and include great difficulty breathing and severe cyanosis (a bluish discoloration of the skin).[1] The exact cause of TGA in most cases is unknown.[2] Surgery is done to correct the abnormality during the first few days of life.[1]
Last updated: 6/27/2011

References

  1. Gregory S. Liptak. Transposition of the Great Arteries. Merck Manuals. April 2006; http://www.merckmanuals.com/home/sec23/ch265/ch265b.html#sec23-ch265-ch265b-306. Accessed 6/27/2011.
  2. Paula Martins and Eduardo Castela. Transposition of the great arteries. Orphanet Journal of Rarer Diseases. October 2008; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577629/?tool=pubmed. Accessed 6/27/2011.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

1 question(s) from the public on Transposition of the great arteries have been answered. See questions and answers. You can also submit a new question.

Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers. 

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Transposition of the great arteries. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Dextro-looped transposition of the great arteries
  • DTGA
  • TGA
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.