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Genetic and Rare Diseases Information Center (GARD)

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Transposition of the great arteries

Other Names for this Disease
  • Dextro-looped transposition of the great arteries
  • DTGA
  • TGA
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What causes transposition of the great arteries (TGA)?

The exact cause of TGA remains unknown. Some possible associated risk factors that have been proposed include gestational diabetes mellitus, maternal exposure to rodenticides and herbicides, and maternal use of anti-epileptic drugs. Changes (mutations) in specific genes including the GDF1, CFC1 and MED13L (also called THRAP2) genes have been implicated in only a small minority of TGA cases.[1][2]
Last updated: 6/27/2011

  1. Paula Martins and Eduardo Castela. Transposition of the great arteries. Orphanet Journal of Rarer Diseases. October 2008; Accessed 6/27/2011.
  2. Victor A. McKusick et al. TRANSPOSITION OF THE GREAT ARTERIES, DEXTRO-LOOPED 1; DTGA1. OMIM. October 10, 2007; Accessed 6/27/2011.