Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Transposition of the great arteries


Other Names for this Disease

  • Dextro-looped transposition of the great arteries
  • DTGA
  • TGA
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Cause

Newline Maker

What causes transposition of the great arteries (TGA)?

The exact cause of TGA remains unknown. Some possible associated risk factors that have been proposed include gestational diabetes mellitus, maternal exposure to rodenticides and herbicides, and maternal use of anti-epileptic drugs. Changes (mutations) in specific genes including the GDF1, CFC1 and MED13L (also called THRAP2) genes have been implicated in only a small minority of TGA cases.[1][2]
Last updated: 6/27/2011

References
  1. Paula Martins and Eduardo Castela. Transposition of the great arteries. Orphanet Journal of Rarer Diseases. October 2008; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577629/?tool=pubmed. Accessed 6/27/2011.
  2. Victor A. McKusick et al. TRANSPOSITION OF THE GREAT ARTERIES, DEXTRO-LOOPED 1; DTGA1. OMIM. October 10, 2007; http://www.ncbi.nlm.nih.gov/omim/608808. Accessed 6/27/2011.


Other Names for this Disease
  • Dextro-looped transposition of the great arteries
  • DTGA
  • TGA
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.