Other Names for this Disease
- Diffuse cutaneous mastocytosis
- Telangiectasia macularis eruptiva perstans
- Urticaria pigmentosa
Your QuestionWhat medications and/or treatments can I use for this condition? The itching is driving me crazy. At the moment I take anti-histamines, would PUVA treatments help? Will this condition ever leave?
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Therapy for cutaneous mastocytosis aims to relieve symptoms. Medications such as antihistamines and disodium cromoglycate (cromolyn) are available to target most skin and stomach-related symptoms. 
Other medications may be recommended for symptoms of more severe and unusual forms of cutaneous mastocytosis. Corticosteroid therapy, both applied to the skin (topical) and by injection, as well as aspirin may be helpful for some individuals whose symptoms don't improve with antihistamines. Some severe cases of cutaneous mastocytosis may respond to ultraviolet light therapy such as psoralen plus UV-A (PUVA). These therapies must be carefully administered by a healthcare professional due to potentially severe reactions. 
Last updated: 10/8/2012
The outcome for individuals with cutaneous mastocytosis is generally good. In about half of the affected children, the condition goes away by puberty. Symptoms usually improve in others as they reach adulthood. In adults, persistent cutaneous mastocytosis may develop into a more serious condition called systemic mastocytosis that may lead to severe or disabling manifestations. Regular evaluations are needed to check for signs of systemic disease. 
Last updated: 11/11/2010
- Hogan D, Mastrodomenico CM. Mastocytosis: Treatment & Medication. Medscape Reference. June 2012; http://emedicine.medscape.com/article/1057932-treatment. Accessed 10/8/2012.
- Lehrer M. Urticaria pigmentosa. MedlinePlus. 10/28/2008; www.nlm.nih.gov/medlineplus/ency/article/001466.htm. Accessed 11/10/2010.
- Flageul B. Cutaneous mastocytosis. Orphanet. October, 2006; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=66646. Accessed 11/10/2010.