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Genetic and Rare Diseases Information Center (GARD)

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Cutaneous mastocytosis


Other Names for this Disease

  • Diffuse cutaneous mastocytosis
  • Mastocytoma
  • Telangiectasia macularis eruptiva perstans
  • Urticaria pigmentosa
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Overview

Cutaneous mastocytosis is a condition caused by the accumulation of mast cells in the skin. Mast cells contain substances such as histamine that regulate allergic reactions. This condition is usually diagnosed in children and typically resolves by puberty. Treatment is generally based on a person's symptoms, but it may include antihistamines to prevent the effect of mast cell histamine.[1]

There are several different types of cutaneous mastocytosis. Urticaria pigmentosa is the most common form and is characterized by brown patches on the skin where mast cells have accumulated. Diffuse cutaneous mastocytosis is a very rare form of the condition that presents at birth with skin that is thickened and easily blistered. A mastocytoma is raised nodule that is also usually seen in infancy. Another rare form that occurs in adults is called telangiectasia macularis eruptiva perstans (TMEP).[2]
Last updated: 10/8/2012

References

  1. Mastocytosis. National Institute of Allergy and Infectious Diseases. January 2011; http://www.niaid.nih.gov/topics/mastocytosis/Pages/overview.aspx. Accessed 5/15/2013.
  2. All About Mastocytosis. The Mastocytosis Society, Inc. 2011; http://tmsforacure.org/patients/mastocytosis_explained_2.php. Accessed 10/5/2012.
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Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information on urticaria pigmentosa and mastocytoma.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers. 
  • The National Institute of Allergy and Infectious Diseases (NIAID) supports scientists developing better ways to diagnose, treat, and prevent the many infectious, immunologic, and allergic diseases that afflict people worldwide. Click on the link to view information on this topic. 
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Cutaneous mastocytosis. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Diffuse cutaneous mastocytosis
  • Mastocytoma
  • Telangiectasia macularis eruptiva perstans
  • Urticaria pigmentosa
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.