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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Vogt-Koyanagi-Harada disease


Other Names for this Disease

  • Uveomenigitic syndrome
  • VKH disease
  • VKH syndrome
  • Vogt-Koyanagi-Harada syndrome
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Your Question

What is the cause of Vogt-Koyanagi-Harada syndrome?

Our Answer

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What causes Vogt-Koyanagi-Harada disease?

The exact cause of Vogt-Koyanagi-Harada (VKH) disease is not well understood, but research suggests it is an autoimmune disease in which the body attacks its own pigment cells (melanocytes), possibly in response to an infection (such as a virus).[1] The strong association between VKH disease and certain ethnic groups suggests that genetic factors may be involved. Genes related to the immune system, namely those genes in the HLA gene family, may play a role in the development of VKH disease.[2]
Last updated: 1/8/2015

References
Other Names for this Disease
  • Uveomenigitic syndrome
  • VKH disease
  • VKH syndrome
  • Vogt-Koyanagi-Harada syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.