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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Vogt-Koyanagi-Harada syndrome


Other Names for this Disease

  • VKH syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Symptoms

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What are the signs and symptoms of Vogt-Koyanagi-Harada syndrome?

Vogt-Koyanagi-Harada syndrome affects the eyes, ears, skin (cutaneous), and nervous system. Early symptoms include headache, dizziness, neck stiffness, vomiting, and low-grade fever. The symptoms progress to sudden visual loss in one or both eyes, eye pain, eye swelling and irritation (uveitis, choroiditis) and hearing disturbances.  Changes in the coloring of the skin and hair are usually observed three months after symptoms first appear and they are often permanent.[1] Vision and hearing generally improve with medical treatment. [2]
Last updated: 3/14/2014

The Human Phenotype Ontology provides the following list of signs and symptoms for Vogt-Koyanagi-Harada syndrome. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Abnormal hair quantity 90%
Abnormality of the eyelashes 90%
Aplasia/Hypoplasia of the eyebrow 90%
Cognitive impairment 90%
Hypopigmented skin patches 90%
Premature graying of hair 90%
Sensorineural hearing impairment 90%
Visual impairment 90%
Cataract 50%
Glaucoma 50%
Retinal detachment 50%
Short stature 50%

Last updated: 9/2/2014

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.


References
  1. Choczaj-Kukula A.. Vogt-Koyanagi-Harada Syndrome. Emedicine. July 15, 2009; http://emedicine.medscape.com/article/1118177-overview. Accessed 10/28/2010.
  2. Fang W, Yang P.. Vogt-Koyanagi-Harada. Current Eye Research. May, 2008; Accessed 10/28/2010.


Other Names for this Disease
  • VKH syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.