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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Von Willebrand disease

*

* Not a rare disease

Other Names for this Disease

  • Von Willebrand factor, deficiency
  • VWD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions. Click on the link to view the article on this topic.
  • The National Hemophilia Foundation Web site posts the guidelines for management of pregnancy and delivery of women with bleeding disorders and carriers of hemophilia A and B. Click on the link to view the guidelines.
  • The National Heart, Blood and Lung Institute (NHLBI) assembled a panel of experts on von Willebrand to develop clinical management guidelines. To view the guidelines, click on the link.

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Von Willebrand disease. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.

Medical Products

The medication(s) listed in the table(s) below have been approved by the Food and Drug Administration (FDA) for treatment of this condition. The FDA Office of Orphan Products Development designates "orphan products" for those that treat rare diseases affecting fewer than 200,000 Americans. The table(s) below may not be an exhaustive list of drugs or products used to treat this condition. There may be other products available that are not considered orphan products. To search for all FDA approved drugs, visit Drugs@FDA. You can find orphan products used to treat other conditions by searching the Orphan Drug Product Designation database.


Generic Name Antihemophilic factor (human)
Trade Name
(Manufacturer Name)
Alphanate®
(Grifols Biologicals Inc.)
Indication
The FDA has approved this product to be used in this manner.
For surgical and/or invasive procedures in patients with von Willebrand Disease (VWD) in whom desmopressin is either ineffective or contraindicated. It is not indicated for patients with severe VWD (Type 3) undergoing major surgery
More Information about this product Drug Information Portal
Medline Plus Health Information

Generic Name Antihemophilic factor/von Willebrand factor complex (human), dried, pasteurized
Trade Name
(Manufacturer Name)
Humate-P®
(CSL Behring)
Indication
The FDA has approved this product to be used in this manner.
(1) In adult patients for treatment and prevention of bleeding in hemophilia A (classic hemophilia) and (2) in adult and pediatric patients for treatment of spontaneous and trauma-induced bleeding episodes in severe von Willebrand disease, and in mild and
More Information about this product Drug Information Portal
Medline Plus Health Information

Generic Name Desmopressin acetate
Trade Name
(Manufacturer Name)
Stimate®
(CSL Behring)
Indication
The FDA has approved this product to be used in this manner.
Treatment of patients with hemophilia A or von Willebrand's disease (type I) whose factor VIII coagulant activity level is greater than 5%.
More Information about this product Drug Information Portal

Generic Name Human Plasma Coagulation Factor VIII And Human Plasma Von Willebrand Factor
Trade Name
(Manufacturer Name)
Wilate(R)
(Octapharma USA, Inc.)
Indication
The FDA has approved this product to be used in this manner.
Treatment of spontaneous or trauma-induced bleeding episodes in patients with severe von Willebrand disease (VWD) as well as patients with mild or moderate VWD in whom the use of desmopressin is known or suspected to be ineffective or contraindicated
More Information about this product Drug Information Portal

Other Names for this Disease
  • Von Willebrand factor, deficiency
  • VWD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.