Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Von Willebrand disease


* Not a rare disease
Other Names for this Disease
  • Von Willebrand factor, deficiency
  • VWD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


Von Willebrand disease is a bleeding disorder that slows the blood clotting process. People with this condition often experience bruising, nosebleeds, and prolonged bleeding or oozing following an injury, surgery, or having a tooth pulled. In severe cases, heavy bleeding occurs after minor trauma or even in the absence of injury. Milder forms of Von Willebrand disease do not involve spontaneous bleeding, and the condition may become apparent only when abnormal bleeding occurs following surgery or a serious injury. Symptoms may change over time. Increased age, pregnancy, exercise, and stress may make bleeding symptoms may become less frequent. This condition is caused by mutations in the VWF gene and can have different inheritance patterns.[1]
Last updated: 9/15/2011


  1. Von Willebrand disease. Genetics Home Reference. February 2008; Accessed 9/15/2011.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

1 question(s) from the public on Von Willebrand disease have been answered. See questions and answers. You can also submit a new question.

Basic Information

  • You can obtain information on this topic from the Centers for Disease Control and Prevention (CDC). The CDC is recognized as the lead federal agency for developing and applying disease prevention and control, environmental health, and health promotion and education activities designed to improve the health of the people of the United States.
  • Genetics Home Reference (GHR) contains information on Von Willebrand disease. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The Merck Manuals Online Medical Library provides information on this condition. Click on the link to view the information.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Von Willebrand disease. Click on the link to view a sample search on this topic.