Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Wiskott Aldrich syndrome


Other Names for this Disease

  • Aldrich syndrome
  • Eczema thrombocytopenia immunodeficiency syndrome
  • IMD 2
  • Immunodeficiency 2
  • WAS
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Wiskott Aldrich syndrome is a condition that affects blood cells and cells of the immune system. It is seen almost exclusively in males.[1] The condition is characterized by a tendency to bleed easily, development of an intensely itchy, scaling skin rash (eczema), and severe recurrent infections.[2] Wiskott Aldrich syndrome is caused by mutations in the WAS gene, which is located on the X chromosome. The condition is inherited in an X-linked recessive pattern. [1] The leading treatment option for Wiskott Aldrich syndrome is bone marrow transplantation. Alternative treatments may include surgery to remove the spleen and other more conservative measures such as antibiotics, IVIG, and avoidance of foods which may cause allergic reactions.[2]
Last updated: 10/27/2010

References

  1. Wiskott-Aldrich syndrome. Genetics Home Reference (GHR). 2008; http://ghr.nlm.nih.gov/condition/wiskott-aldrich-syndrome. Accessed 10/27/2010.
  2. Primary Immunodeficiency. National Institute of Child Health and Human Development (NICHD). 2008; http://www.nichd.nih.gov/publications/pubs/primary_immuno.cfm. Accessed 10/27/2010.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

2 question(s) from the public on Wiskott Aldrich syndrome have been answered. See questions and answers. You can also submit a new question.

Basic Information

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Wiskott Aldrich syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Aldrich syndrome
  • Eczema thrombocytopenia immunodeficiency syndrome
  • IMD 2
  • Immunodeficiency 2
  • WAS
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.