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Wiskott Aldrich syndrome
Other Names for this Disease
- Aldrich syndrome
- Eczema thrombocytopenia immunodeficiency syndrome
- IMD 2
- Immunodeficiency 2
 The condition is characterized by a tendency to bleed easily, development of an intensely itchy, scaling skin rash (eczema), and severe recurrent infections. Wiskott Aldrich syndrome is caused by mutations in the WAS gene, which is located on the X chromosome. The condition is inherited in an X-linked recessive pattern.  The leading treatment option for Wiskott Aldrich syndrome is bone marrow transplantation. Alternative treatments may include surgery to remove the spleen and other more conservative measures such as antibiotics, IVIG, and avoidance of foods which may cause allergic reactions.Wiskott Aldrich syndrome is a condition that affects blood cells and cells of the immune system. It is seen almost exclusively in males.
Last updated: 10/27/2010
- Wiskott-Aldrich syndrome. Genetics Home Reference (GHR). 2008; http://ghr.nlm.nih.gov/condition/wiskott-aldrich-syndrome. Accessed 10/27/2010.
- Primary Immunodeficiency. National Institute of Child Health and Human Development (NICHD). 2008; http://www.nichd.nih.gov/publications/pubs/primary_immuno.cfm. Accessed 10/27/2010.
- The American Society of Gene & Cell Therapy provides information on the treatment of immunodeficiency diseases.
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) provides information related to the health of children, adults, and families. Click on the link to view information on this topic.
- Genetics Home Reference (GHR) contains information on Wiskott Aldrich syndrome. This website is maintained by the National Library of Medicine.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
In Depth Information
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Wiskott Aldrich syndrome. Click on the link to view a sample search on this topic.