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Wolff-Parkinson-White syndrome

Other Names for this Disease
  • Anomalous ventricular excitation syndrome
  • Auriculoventricular accessory pathway syndrome
  • False bundle branch block syndrome
  • Preexcitation syndrome
  • Ventricular familial preexcitation syndrome
More Names
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Wolff-Parkinson-White syndrome is a condition that disrupts the heart's normal rhythm (arrhythmia). People with Wolff-Parkinson-White syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart.  This abnormality leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. In most cases, the cause of Wolff-Parkinson-White syndrome is unknown. A small percentage of cases are caused by mutations in the PRKAG2 gene. These cases appear to be inherited in an autosomal dominant manner.[1] 
Last updated: 12/31/2012


  1. Wolff-Parkinson-White syndrome. Genetics Home Reference (GHR). February 2007; Accessed 8/14/2009.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Wolff-Parkinson-White syndrome. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
  • The American Heart Association has and information page on Wolff-Parkinson-White syndrome on their Web site.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
    Wolff-Parkinson-White syndrome - Pediatric Cardiology
    Wolff-Parkinson-White syndrome - Emergency Medicine
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Wolff-Parkinson-White syndrome. Click on the link to view a sample search on this topic.
  • Medscape Reference has two articles on this topic from the perspective of pediatric cardiology and emergency medicine. You may need to register to view the information online, but registration is free.