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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Wolfram syndrome


Other Names for this Disease

  • Diabetes insipidus and mellitus with optic atrophy and deafness
  • DIDMOAD
  • DIDMOAD syndrome
  • WFS
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might Wolfram syndrome be treated?

Treatment of Wolfram syndrome is supportive and based on the signs and symptoms present in each person. For example, almost all affected people require insulin to treat diabetes mellitus. People with hearing loss may benefit from hearing aids or cochlear implantation.[1][2][3]

For more detailed information regarding the treatment and management of Wolfram syndrome, click here.
Last updated: 12/8/2014

References
  1. Tranebjærg L, Barrett T & Rendtorff ND. WFS1-Related Disorders. Gene Reviews. 2013; http://www.ncbi.nlm.nih.gov/books/NBK4144/. Accessed 1/21/2014.
  2. Wolfram syndrome. Orphanet. September 2014; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=3463.
  3. Wolfram Syndrome. NORD. May 2008; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/850/viewFullReport.


Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions. Click on the link to view the article on this topic.

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Wolfram syndrome. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
  • The Research Portfolio Online Reporting Tool (RePORT) provides access to reports, data, and analyses of research activities at the National Institutes of Health (NIH), including information on NIH expenditures and the results of NIH-supported research. Although these projects may not conduct studies on humans, you may want to contact the investigators to learn more. To search for studies, enter the disease name in the "Text Search" box. Then click "Submit Query".
Other Names for this Disease
  • Diabetes insipidus and mellitus with optic atrophy and deafness
  • DIDMOAD
  • DIDMOAD syndrome
  • WFS
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.