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Other Names for this Disease
- Pancreatic ulcerogenic tumor syndrome
- Z E syndrome
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gastrinomas in the pancreas and duodenum (part of the small intestine) cause high levels of the hormone gastrin in the blood. High levels of gastrin then cause production of too much stomach acid. Signs and symptoms may include abdominal pain, peptic ulcers, vomiting blood, and diarrhea. The tumors are sometimes cancerous and may spread to other areas of the body. In most cases, the cause of ZES is unknown. However, about 25-30% of gastrinomas are caused by an inherited condition called multiple endocrine neoplasia type 1 (MEN1). Treatment for ZES may include medication to reduce the production of stomach acid, and surgery for peptic ulcers or to remove tumors.Zollinger-Ellison syndrome (ZES) is a condition in which tumors called
Last updated: 1/14/2014
- David C. Dugdale, III and George F. Longstreth. Zollinger-Ellison syndrome. MedlinePlus. November 11, 2010; http://www.nlm.nih.gov/medlineplus/ency/article/000325.htm. Accessed 1/14/2014.
- Elliot M. Livstone. Pancreatic Endocrine Tumors. Merck Manuals. October, 2012; http://www.merckmanuals.com/professional/gastrointestinal_disorders/tumors_of_the_gi_tract/pancreatic_endocrine_tumors.html?qt=&sc=&alt=. Accessed 1/14/2014.
- Zollinger-Ellison Syndrome. National Digestive Diseases Information Clearinghouse (NDDIC). December 24, 2013; http://www.digestive.niddk.nih.gov/ddiseases/pubs/zollinger/. Accessed 1/14/2014.
- Zollinger-Ellison Syndrome. National Digestive Diseases Information Clearinghouse (NDDIC). May 10, 2012; http://digestive.niddk.nih.gov/ddiseases/pubs/zollinger/. Accessed 10/28/2012.
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- The Merck Manuals Online Medical Library provides information on this condition. Click on the link to view the information.
- The National Digestive Diseases Information Clearinghouse (NDDIC), part of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), offers information on this condition. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
In Depth Information
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Zollinger-Ellison syndrome. Click on the link to go to OMIM and review these resources.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Zollinger-Ellison syndrome. Click on the link to view a sample search on this topic.