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Genetic and Rare Diseases Information Center (GARD)

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HTLV-1 associated myelopathy/tropical spastic paraparesis

Other Names for this Disease
  • Human T-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis
  • Tropical spastic paraparesis (formerly)
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How might HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) be treated?

There is no established treatment program for HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP).  Corticosteroids may relieve some symptoms, but aren’t likely to change the course of the disorder.  Clinical studies suggest that interferon alpha provides benefits over short periods and some aspects of disease activity may be improved favorably using interferon beta. Stiff and spastic muscles may be treated with lioresal or tizanidine.  Urinary dysfunction may be treated with oxybutynin.[1]
Last updated: 3/16/2011

  1. Tropical Spastic Paraparesis. National Institute of Neurological Disorders and Stroke. May 9, 2007; Accessed 3/17/2008.

Clinical Trials & Research for this Disease

  • lists trials that are studying or have studied HTLV-1 associated myelopathy/tropical spastic paraparesis. Click on the link to go to to read descriptions of these studies.
  • The Research Portfolio Online Reporting Tool (RePORT) provides access to reports, data, and analyses of research activities at the National Institutes of Health (NIH), including information on NIH expenditures and the results of NIH-supported research. Although these projects may not conduct studies on humans, you may want to contact the investigators to learn more. To search for studies, click on the link and enter the disease name in the "Terms Search" box. Then click "Submit Query".