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Other Names for this Disease
- Familial Felty's syndrome
- Felty syndrome
- Rheumatoid arthritis, splenomegaly and neutropenia
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Felty's syndrome is a rare, potentially serious disorder that is defined by the presence of three conditions: rheumatoid arthritis (RA), an enlarged spleen (splenomegaly) and a decreased white blood cell count (neutropenia), which causes repeated infections. Although some individuals with Felty's syndrome are asymptomatic, others can develop serious and life-threatening infections. Symptoms of Felty's syndrome, in addition to those associated with the three conditions stated above, may include fatigue, fever, weight loss, discoloration of patches of skin, mild hepatomegaly (enlarged liver), lymphadenopathy (swelling of lymph nodes), Sjögren syndrome, vasculitis, lower-extremity ulcers, and other findings. The exact cause is unknown, but several risk factors have been proposed, including autoimmunity. A few familial cases of the condition have been reported. Treatment typically focuses on controlling the underlying RA; immunosuppressive therapy for RA may improve neutropenia and splenomegaly.
- Felty Syndrome. NORD. http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Felty%20Syndrome. Accessed January 6, 2011.
- Richard M Keating. Felty syndrome. eMedicine. http://emedicine.medscape.com/article/329734-overview. Accessed January 6, 2011.
- Runge LA, Davey FR, Goldberg J, Boyd PR. The inheritance of Felty's syndrome in a family with several affected members. Journal of Rheumatology. February 1986. http://www.ncbi.nlm.nih.gov/pubmed/3701742. Accessed January 6, 2011.
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- The The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Felty's syndrome. Click on the link to go to OMIM and review these resources.