Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Fibrosing mediastinitis

Other Names for this Disease
  • Idiopathic mediastinal fibrosis
  • Mediastinal fibrosis
  • Sclerosing mediastinitis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


Fibrosing mediastinitis refers to scarring in the chest that can entrap the esophagus, the heart, the lymph nodes, and the major blood vessels that carry blood to and from the heart.[1] The “mediastinum” refers specifically to the area between the lungs. The scarring may involve a single mass or be diffusely spread throughout the cavity.  In rare cases, fibrosing mediastinitis may extend into the soft tissues of the neck, the back of the chest, and into the lung.[2]
Last updated: 4/23/2010


  1. Histioplasmosis. MedlinePlus. 2008; Accessed 4/22/2010.
  2. Rossi S, McAdams H, Rosado-de-Christenson M, Franks T, Galvin J. Fibrosing Mediastinitis. Radiographics. 2001;
  3. MacDonald S, Padley S. The mediastinum, including the pericardium. In: Adam A, Dixon AK. Grainger & Allison’s Diagnostic Radiology, 5th ed. Philadelphia, PA: Churchill Livingston; 2008;
  4. Worrell JA, Donnelly EF, Martin JB, Bastarache JA, Loyd JE. Computed tomography and the idiopathic form of proliferative fibrosing mediastinits. J Thorac Imaging. 2007;
  5. Devaraj A, Griffin N, Nicholson AG, Padley SPG. Computed tomography findings in fibrosing mediastinitis. Clinical Radiology. 2007;
  6. Peebles RS, Carpenter CT, Dupont WD, Loyd JE. Medistinal fibrosis is associated with human leukocyte antigen-A2*. CHEST. 2000;
Your Questions Answered
by the Genetic and Rare Diseases Information Center

2 question(s) from the public on Fibrosing mediastinitis have been answered. See questions and answers. You can also submit a new question.

Basic Information

  • MedlinePlus provides more information on mediastinitis and histoplasmosis. MedlinePlus is a Web site designed by the National Library of Medicine to help you research your health questions. To view the information pages click on the links above.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Fibrosing mediastinitis. Click on the link to view a sample search on this topic.

Selected Full-Text Journal Articles