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Genetic and Rare Diseases Information Center (GARD)

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Periodic fever, familial, autosomal dominant


Other Names for this Disease

  • Familial Hibernian fever
  • FHF
  • FPF
  • Hibernian fever, familial
  • TNF receptor-associated periodic syndrome
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Overview

Familial autosomal dominant periodic fever is an inherited condition characterized by episodes of fever, abdominal pain, diarrhea, painful red skin rashes, muscle pain and swelling around the eye. The former name of this syndrome was familial Hibernian fever and it is sometimes referred to as tumor necrosis factor receptor associated periodic syndrome or TRAPS.[1] Familial autosomal dominant periodic fever is caused by mutations in the Tumor Necrosis Factor Receptor gene (TNFRSF1A), which are inherited in an autosomal dominant fashion.[1][2] Although there is no proven definitive treatment to prevent or cure this condition, various anti-inflammatory agents may help to relieve symptoms. Nonetheless, most patients will experience episodes of symptoms throughout their life.[1] 
Last updated: 1/9/2009

References

  1. Periodic Fever Syndromes. Cleveland Clinic Department of Rheumatic and Immunologic Diseases. 2009; http://my.clevelandclinic.org/disorders/periodic_fever_syndrome/rheumatology_overview.aspx. Accessed 1/9/2009.
  2. Shinawi M, Scaglia F. Hereditary Periodic Fever Syndromes. eMedicine. November 4, 2008; http://emedicine.medscape.com/article/952254-overview. Accessed 1/9/2009.
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  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Periodic fever, familial, autosomal dominant. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Familial Hibernian fever
  • FHF
  • FPF
  • Hibernian fever, familial
  • TNF receptor-associated periodic syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.