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Periodic fever, familial, autosomal dominant

Other Names for this Disease
  • Familial Hibernian fever
  • FHF
  • FPF
  • Hibernian fever, familial
  • TNF receptor-associated periodic syndrome
More Names
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Familial autosomal dominant periodic fever is an inherited condition characterized by episodes of fever, abdominal pain, diarrhea, painful red skin rashes, muscle pain and swelling around the eye. The former name of this syndrome was familial Hibernian fever and it is sometimes referred to as tumor necrosis factor receptor associated periodic syndrome or TRAPS.[1] Familial autosomal dominant periodic fever is caused by mutations in the Tumor Necrosis Factor Receptor gene (TNFRSF1A), which are inherited in an autosomal dominant fashion.[1][2] Although there is no proven definitive treatment to prevent or cure this condition, various anti-inflammatory agents may help to relieve symptoms. Nonetheless, most patients will experience episodes of symptoms throughout their life.[1] 
Last updated: 1/9/2009


  1. Periodic Fever Syndromes. Cleveland Clinic Department of Rheumatic and Immunologic Diseases. 2009; Accessed 1/9/2009.
  2. Shinawi M, Scaglia F. Hereditary Periodic Fever Syndromes. eMedicine. November 4, 2008; Accessed 1/9/2009.
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  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
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