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Periodic fever, familial, autosomal dominant
Other Names for this Disease
- Familial Hibernian fever
- Hibernian fever, familial
- TNF receptor-associated periodic syndrome
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Familial autosomal dominant periodic fever is an inherited condition characterized by episodes of fever, abdominal pain, diarrhea, painful red skin rashes, muscle pain and swelling around the eye. The former name of this syndrome was familial Hibernian fever and it is sometimes referred to as tumor necrosis factor receptor associated periodic syndrome or TRAPS. Familial autosomal dominant periodic fever is caused by mutations in the Tumor Necrosis Factor Receptor gene (TNFRSF1A), which are inherited in an autosomal dominant fashion. Although there is no proven definitive treatment to prevent or cure this condition, various anti-inflammatory agents may help to relieve symptoms. Nonetheless, most patients will experience episodes of symptoms throughout their life.
- Periodic Fever Syndromes. Cleveland Clinic Department of Rheumatic and Immunologic Diseases. http://my.clevelandclinic.org/disorders/periodic_fever_syndrome/rheumatology_overview.aspx. Accessed January 9, 2009.
- Shinawi M, Scaglia F. Hereditary Periodic Fever Syndromes. eMedicine. http://emedicine.medscape.com/article/952254-overview. Accessed January 9, 2009.
On this page
- The Cleveland Clinic provides an overview of the different types of periodic fever syndromes.
- Genetics Home Reference (GHR) contains information on Periodic fever, familial, autosomal dominant. Click on the link to go to GHR and review the information.
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- The Merck Manuals Online Medical Library provides information on this condition. Click on the link to view the information.
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) offers printed materials on this topic. We recommend calling toll-free at 877-226-4267 to request a copy of this information.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge. Click on the link to read information on this topic.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Periodic fever, familial, autosomal dominant. Click on the link to view a sample search on this topic.
- The The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Periodic fever, familial, autosomal dominant. Click on the link to go to OMIM and review these resources.