Periodic fever, familial, autosomal dominant
Other Names for this Disease
- Familial Hibernian fever
- Hibernian fever, familial
- TNF receptor 1 associated periodic syndrome
 Familial autosomal dominant periodic fever is caused by mutations in the Tumor Necrosis Factor Receptor gene (TNFRSF1A), which are inherited in an autosomal dominant fashion. Although there is no proven definitive treatment to prevent or cure this condition, various anti-inflammatory agents may help to relieve symptoms. Nonetheless, most patients will experience episodes of symptoms throughout their life.Familial autosomal dominant periodic fever is an inherited condition characterized by episodes of fever, abdominal pain, diarrhea, painful red skin rashes, muscle pain and swelling around the eye. The former name of this syndrome was familial Hibernian fever and it is sometimes referred to as tumor necrosis factor receptor associated periodic syndrome or TRAPS.
Last updated: 1/9/2009
- Periodic Fever Syndromes. Cleveland Clinic Department of Rheumatic and Immunologic Diseases. 2009; http://my.clevelandclinic.org/disorders/periodic_fever_syndrome/rheumatology_overview.aspx. Accessed 1/9/2009.
- Shinawi M, Scaglia F. Hereditary Periodic Fever Syndromes. eMedicine. November 4, 2008; http://emedicine.medscape.com/article/952254-overview. Accessed 1/9/2009.
- The Cleveland Clinic provides an overview of the different types of periodic fever syndromes.
- Genetics Home Reference (GHR) contains information on Periodic fever, familial, autosomal dominant. This website is maintained by the National Library of Medicine.
- The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers.
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- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
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