Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Autoimmune polyglandular syndrome type 1


Other Names for this Disease

  • APS 1
  • Autoimmune polyendocrine syndrome type 1
  • Autoimmune polyendocrinopathy syndrome type 1
  • Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
  • Hypoadrenocorticism with hypoparathyroidism and superficial moniliasis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

How rare is autoimmune polyglandular syndrome type 1?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is autoimmune polyglandular syndrome type 1?

Autoimmune polyglandular syndrome type 1 is an inherited autoimmune condition that affects many of the body's organs. Symptoms often begin in childhood or adolescence and may include mucocutaneous candidiasis, hypoparathyroidism, and Addison disease. Affected individuals typically have at least two of these features, and many have all three. This syndrome can cause a variety of additional signs and symptoms, although they occur less often. Complications of this disorder can affect the skin and nails, the gonads (ovaries and testicles), the eyes, the thyroid, and the digestive system. Type 1 diabetes also occurs in some patients with this condition. Mutations in the AIRE gene cause autoimmune polyglandular syndrome, type 1. This condition is inherited in an autosomal recessive fashion.[1]
Last updated: 5/28/2009

How rare is autoimmune polyglandular syndrome type 1?

Autoimmune polyglandular syndrome type 1 is thought to be a rare condition, with about 500 cases reported worldwide. This condition occurs more frequently in certain populations, including Iranian Jews, Sardinians, and Finns.[1]
Last updated: 5/29/2009

References
Other Names for this Disease
  • APS 1
  • Autoimmune polyendocrine syndrome type 1
  • Autoimmune polyendocrinopathy syndrome type 1
  • Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
  • Hypoadrenocorticism with hypoparathyroidism and superficial moniliasis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.