Attenuated familial adenomatous polyposis
Other Names for this Disease
- Attenuated adenomatous polyposis coli
- Attenuated familial polyposis coli
- Attenuated FAP
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colon polyps (an average of 30) than in classic FAP, and the polyps tend to occur more proximally in the colon. The average age of colon cancer diagnosis in affected individuals is 50 to 55 years, which is 10 to 15 years later than in those with classic FAP, but earlier than when colon cancer occurs in the general population. In addition to colon polyps, findings may include upper gastrointestinal polyps and cancers; non-intestine related signs of FAP (but CHRPE and desmoid tumors are rare); and thyroid cancer. AFAP is caused by mutations in the APC gene and is inherited in an autosomal dominant manner.Attenuated familial adenomatous polyposis (AFAP) is a cancer predisposition syndrome characterized by a significant risk to develop colon cancer. Individuals with AFAP generally have fewer
Last updated: 12/16/2011
- Jasperson KW, Burt RW. APC-Associated Polyposis Conditions. GeneReviews. October 27, 2011; http://www.ncbi.nlm.nih.gov/books/NBK1345/. Accessed 2/17/2012.
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