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Attenuated familial adenomatous polyposis

Other Names for this Disease
  • AAPC
  • AFAP
  • Attenuated adenomatous polyposis coli
  • Attenuated familial polyposis coli
  • Attenuated FAP
More Names
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How might attenuated familial adenomatous polyposis be treated?

Management of AFAP is generally based on continued surveillance to detect if and when the formation of polyps occurs.[1] Screening by colonoscopy and endoscopy has been recommended for affected individuals starting at the age of 20 to 25 years. Individuals with polyps may undergo polypectomy (removal of polyps), followed by continued yearly surveillance. Individuals with too many adenomas to remove during endoscopy, or those who cannot undergo surveillance, may consider a prophylactic colectomy (removal of all or part of the colon).[2] About one third of individuals with AFAP have few enough colon polyps that surveillance with periodic polypectomy is sufficient.[3] Because individuals with AFAP can also develop duodenal adenomas and other cancers, upper endoscopy is typically recommended starting at age 20 to 30 years and then every one to three years, depending on the number of polyps. There is currently no consensus on screening for tumors that occur outside of the colon, so it has been suggested that affected individuals are managed as if they have classic FAP.[2] A number of drugs such as celecoxib and sulindac reportedly have been successful at reducing the number and the size of polyps in affected individuals, but these drugs generally help to prevent further complications and are not considered sufficient treatment.[1]

Additional and more detailed information about the treatment and management of FAP, including AFAP, is available on eMedicine's Web site and can be viewed by clicking here.
Last updated: 12/16/2011

  1. Mohammad Wehbi. Familial Adenomatous Polyposis. eMedicine. September 1, 2011; Accessed 12/16/2011.
  2. Peter A L Bonis, Dennis J Ahnen, Lisen Axell. Familial adenomatous polyposis and MUTYH associated polyposis: Screening and management of patients and families. UpToDate. Waltham, MA: UpToDate; 2011;
  3. Jasperson KW, Burt RW. APC-Associated Polyposis Conditions. GeneReviews. October 27, 2011; Accessed 2/17/2012.

Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions. Click on the link to view the article on this topic.

Clinical Trials & Research for this Disease

  • lists trials that are studying or have studied Attenuated familial adenomatous polyposis. Click on the link to go to to read descriptions of these studies.