Attenuated familial adenomatous polyposis
Other Names for this Disease
- Attenuated adenomatous polyposis coli
- Attenuated familial polyposis coli
- Attenuated FAP
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familial adenomatous polyposis that is characterized by fewer colon polyps (an average of 30) and a delay in the development of colon cancer (average age 50 to 55 years). Other signs and symptoms may include dental abnormalities; desmoid tumors; and benign and malignant (cancerous) tumors of the duodenum (a section of the small intestine), stomach, bones, skin, thyroid and other tissues. AFAP is caused by mutations in the APC gene and is inherited in an autosomal dominant manner. AFAP is generally managed with regular screening to detect if and when polyps develop.Attenuated familial adenomatous polyposis (AFAP) is an inherited condition that causes cancer of the large intestine (colon) and rectum. It is a milder form of classic
Last updated: 11/28/2014
- Kory W Jasperson, MS and Randall W Burt, MD. APC-Associated Polyposis Conditions. GeneReviews. March 27, 2014; http://www.ncbi.nlm.nih.gov/books/NBK1345/.
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