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Genetic and Rare Diseases Information Center (GARD)

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Moebius syndrome


Other Names for this Disease
  • Absence or underdevelopment of the 6th and 7th cranial nerves
  • Congenital facial diplegia
  • Congenital facial diplegia syndrome
  • Congenital oculofacial paralysis
  • MBS
More Names
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Overview


Moebius syndrome is a rare neurological condition that primarily affects the muscles that control facial expression and eye movement. Signs and symptoms of the condition may include weakness or paralysis of the facial muscles; feeding, swallowing, and choking problems; excessive drooling; crossed eyes; lack of facial expression; eye sensitivity; high or cleft palate; hearing problems; dental abnormalities; bone abnormalities in the hands and feet; and/or speech difficulties.[1][2] Affected children often experience delayed development of motor skills (such as crawling and walking), although most eventually acquire these skills.[1] Moebius syndrome is caused by the absence or underdevelopment of the 6th and 7th cranial nerves, which control eye movement and facial expression. Other cranial nerves may also be affected.[2] There is no cure for Moebius syndrome, but proper care and treatment give many individuals a normal life expectancy.[2]
Last updated: 7/15/2013

References

  1. Moebius syndrome. Genetics Home Reference. July 2010; http://ghr.nlm.nih.gov/condition/moebius-syndrome. Accessed 3/11/2011.
  2. NINDS Moebius Syndrome Information Page. National Institute of Neurological Disorders and Stroke, National Institutes of Health. September 16, 2008; http://www.ninds.nih.gov/disorders/mobius/moebius.htm. Accessed 3/11/2011.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Moebius syndrome. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • OMIM is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Moebius syndrome. Click on the link to view a sample search on this topic.