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Genetic and Rare Diseases Information Center (GARD)

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Dense deposit disease

Other Names for this Disease
  • DDD
  • Glomerulonephritis membranoproliferative type 2
  • Membranoproliferative glomerulonephritis type 2
  • Membranoproliferative glomerulonephritis type II
  • Mesangiocapillary glomerulonephritis type 2
More Names
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Your Question

I have dense deposit disease. Are nausea and vomiting symptoms of the disease?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What are the signs and symptoms of dense deposit disease?

The major features of dense deposit disease (DDD) result from kidney malfunction. They usually include increased protein in the urine (proteinuria); the presence of blood in the urine (hematuria); reduced amounts of urine; low levels of protein in the blood; and swelling in many areas of the body. The kidney problems associated with DDD tend to worsen over time, and about half of affected people develop end-stage renal disease (ESRD) within 10 years after symptoms start.[1]

Some people with DDD develop a buildup of yellowish deposits called drusen in the retina of the eye. These deposits usually appear in childhood or adolescence and can cause vision problems later in life.[1] The long-term risk of vision problems in people with DDD is about 10% (1 in 10).[2]

DDD can sometimes be associated with other conditions that are not related to kidney function. For example, it can occur with acquired partial lipodystrophy (APL), a condition characterized by a lack of fatty tissue under the skin of the upper body.[1] In people with APL, the loss of fat in the upper body usually occurs several years before kidney disease starts.[2]
Last updated: 2/24/2014

Have nausea and vomiting been associated with dense deposit disease?

A review of available literature does not yield reports of individuals with dense deposit disease experiencing nausea and/or vomiting as symptoms of the condition. However, nausea has been reported as an adverse reaction to some therapies being investigated or used to treat the condition.[3]
Last updated: 3/29/2011