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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Dense deposit disease


Other Names for this Disease

  • DDD
  • Glomerulonephritis membranoproliferative type 2
  • Membranoproliferative glomerulonephritis type 2
  • Membranoproliferative glomerulonephritis type II
  • Mesangiocapillary glomerulonephritis type 2
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Overview

Dense deposit disease (DDD) is a condition that primarily affects kidney function. Signs and symptoms usually start between the ages of 5 and 15 but may also begin in adulthood. The major features of DDD are due to kidney malfunction, and often include proteinuria; hematuria; reduced amounts of urine; low levels of protein in the blood; and swelling in many areas of the body. About half of affected people develop end-stage renal disease (ESRD) within 10 years after symptoms start. DDD can have genetic or non-genetic causes. It can be caused by mutations in the C3 and CFH genes; it may develop as a result of both genetic risk factors and environmental triggers; or it can result from the presence of autoantibodies that block the activity of proteins needed for the body's immune response. Most cases are sporadic (occurring by chance in people with no history of the disorder in their family).[1]
Last updated: 2/24/2014

References

  1. Dense deposit disease. Genetics Home Reference. February 2011; http://ghr.nlm.nih.gov/condition/dense-deposit-disease. Accessed 3/29/2011.
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Basic Information

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Dense deposit disease. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • DDD
  • Glomerulonephritis membranoproliferative type 2
  • Membranoproliferative glomerulonephritis type 2
  • Membranoproliferative glomerulonephritis type II
  • Mesangiocapillary glomerulonephritis type 2
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.