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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Dense deposit disease


Other Names for this Disease

  • DDD
  • Glomerulonephritis membranoproliferative type 2
  • Membranoproliferative glomerulonephritis type 2
  • Membranoproliferative glomerulonephritis type II
  • Mesangiocapillary glomerulonephritis type 2
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Inheritance

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Is dense deposit disease inherited?

Most cases of dense deposit disease (DDD) are not inherited, but occur sporadically (in people with no history of the condition in the family). Only a few reported families have had more than one affected family member.[1] The genetics of DDD is complex, and in many cases, its inheritance it is not completely understood. For these reasons, the exact recurrence risk for family members of most affected people is not known but is likely very low.[2]

In people with DDD that are known to have disease-causing mutations in the CFH gene, the inheritance pattern is autosomal recessive. The children of a person with autosomal recessive DDD will definitely be carriers of the condition. Carriers of autosomal recessive conditions typically do not have any signs or symptoms. Genetic carrier testing for at-risk family members is possible if the two CFH mutations have been identified in the affected family member.[2]

DDD has been seen in families in which other relatives have autoimmune disorders, such as celiac disease and type 1 diabetes mellitus.[1]

Individuals who have questions or concerns about the risk to themselves or family members should speak with a genetics professional.
Last updated: 12/15/2014

References
  1. Dense Deposit Disease. Genetics Home Reference. February, 2011; http://ghr.nlm.nih.gov/condition/dense-deposit-disease. Accessed 2/24/2014.
  2. Johnny Cruz Corchado and Richard JH Smith. Dense Deposit Disease/Membranoproliferative Glomerulonephritis Type II. GeneReviews. May 19, 2011; http://www.ncbi.nlm.nih.gov/books/NBK1425/. Accessed 2/24/2014.


Other Names for this Disease
  • DDD
  • Glomerulonephritis membranoproliferative type 2
  • Membranoproliferative glomerulonephritis type 2
  • Membranoproliferative glomerulonephritis type II
  • Mesangiocapillary glomerulonephritis type 2
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.