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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Dense deposit disease


Other Names for this Disease

  • DDD
  • Glomerulonephritis membranoproliferative type 2
  • Membranoproliferative glomerulonephritis type 2
  • Membranoproliferative glomerulonephritis type II
  • Mesangiocapillary glomerulonephritis type 2
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Symptoms

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What are the signs and symptoms of dense deposit disease?

The major features of dense deposit disease (DDD) result from kidney malfunction. They usually include increased protein in the urine (proteinuria); the presence of blood in the urine (hematuria); reduced amounts of urine; low levels of protein in the blood; and swelling in many areas of the body. The kidney problems associated with DDD tend to worsen over time, and about half of affected people develop end-stage renal disease (ESRD) within 10 years after symptoms start.[1]

Some people with DDD develop a buildup of yellowish deposits called drusen in the retina of the eye. These deposits usually appear in childhood or adolescence and can cause vision problems later in life.[1] The long-term risk of vision problems in people with DDD is about 10% (1 in 10).[2]

DDD can sometimes be associated with other conditions that are not related to kidney function. For example, it can occur with acquired partial lipodystrophy (APL), a condition characterized by a lack of fatty tissue under the skin of the upper body.[1] In people with APL, the loss of fat in the upper body usually occurs several years before kidney disease starts.[2]
Last updated: 2/24/2014

The Human Phenotype Ontology provides the following list of signs and symptoms for Dense deposit disease. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Autosomal dominant inheritance -
Autosomal recessive inheritance -
Chronic kidney disease -
Decreased serum complement factor H -
Dense deposit disease -
Depletion of components of the alternative complement pathway -
Hematuria -
Juvenile onset -
Phenotypic variability -
Recurrent bacterial infections -
Thickening of the glomerular basement membrane -

Last updated: 11/3/2014

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.


References
  1. Dense deposit disease. Genetics Home Reference. February 2011; http://ghr.nlm.nih.gov/condition/dense-deposit-disease. Accessed 3/29/2011.
  2. Richard JH Smith, Sanjeev Sethi, Peter F Zipfel. Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type II. GeneReviews. January 2, 2008; http://www.ncbi.nlm.nih.gov/books/NBK1425/. Accessed 3/29/2011.


Other Names for this Disease
  • DDD
  • Glomerulonephritis membranoproliferative type 2
  • Membranoproliferative glomerulonephritis type 2
  • Membranoproliferative glomerulonephritis type II
  • Mesangiocapillary glomerulonephritis type 2
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.