Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Dense deposit disease

Other Names for this Disease
  • DDD
  • Glomerulonephritis membranoproliferative type 2
  • Membranoproliferative glomerulonephritis type 2
  • Membranoproliferative glomerulonephritis type II
  • Mesangiocapillary glomerulonephritis type 2
More Names
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


Newline Maker

What are the signs and symptoms of dense deposit disease?

The major features of dense deposit disease (DDD) result from kidney malfunction. They usually include increased protein in the urine (proteinuria); the presence of blood in the urine (hematuria); reduced amounts of urine; low levels of protein in the blood; and swelling in many areas of the body. The kidney problems associated with DDD tend to worsen over time, and about half of affected people develop end-stage renal disease (ESRD) within 10 years after symptoms start.[1]

Some people with DDD develop a buildup of yellowish deposits called drusen in the retina of the eye. These deposits usually appear in childhood or adolescence and can cause vision problems later in life.[1] The long-term risk of vision problems in people with DDD is about 10% (1 in 10).[2]

DDD can sometimes be associated with other conditions that are not related to kidney function. For example, it can occur with acquired partial lipodystrophy (APL), a condition characterized by a lack of fatty tissue under the skin of the upper body.[1] In people with APL, the loss of fat in the upper body usually occurs several years before kidney disease starts.[2]
Last updated: 2/24/2014

  1. Dense deposit disease. Genetics Home Reference. February 2011; Accessed 3/29/2011.
  2. Richard JH Smith, Sanjeev Sethi, Peter F Zipfel. Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type II. GeneReviews. January 2, 2008; Accessed 3/29/2011.