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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Morgagni-Stewart-Morel syndrome

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Other Names for this Disease

  • Hyperostosis frontalis interna, obesity, shortness and cognitive impairment
  • MSM syndrome
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Symptoms

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What are the signs and symptoms of Morgagni-Stewart-Morel syndrome?

The signs and symptoms of Morgagni-Stewart-Morel (MSM) syndrome typically include the characteristic X-ray finding of thickening of the frontal bone of the skull (hyperostosis frontalis interna) and may also include headache, vertigo, hirsutism, menstrual disorders, galactorrhea, obesity, depression, irritability, fatigability, temporary paralysis on one side of the body, hearing impairment, paralysis of the cranial nerves, muscle weakness, and seizures.[1]
Last updated: 3/28/2011

The Human Phenotype Ontology provides the following list of signs and symptoms for Morgagni-Stewart-Morel syndrome. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Autosomal dominant inheritance -
Diabetes mellitus -
Elevated alkaline phosphatase -
Galactorrhea -
Hyperostosis frontalis interna -
Hypertrichosis -
Menstrual irregularities -
Obesity -
Prolactin excess -

Last updated: 9/2/2014

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.


References
  1. Nallegowda M, Singh U, Khanna M, Yadav SL, Choudhary AR, Thakar A . Morgagni Stewart morel syndrome-Additional features. Neurology India. 2005; http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2005;volume=53;issue=1;spage=117;epage=119;aulast=Nallegowda. Accessed 2/28/2008.


Other Names for this Disease
  • Hyperostosis frontalis interna, obesity, shortness and cognitive impairment
  • MSM syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.