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Genetic and Rare Diseases Information Center (GARD)

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Morgagni-Stewart-Morel syndrome


Other Names for this Disease

  • Hyperostosis frontalis interna, obesity, shortness and cognitive impairment
  • MSM syndrome
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What is Morgagni-Stewart-Morel syndrome?

Morgagni-Stewart-Morel (MSM) syndrome is a condition characterized by thickening of the frontal bone of the skull (hyperostosis frontalis interna), as well as obesity and excessive hair growth (hypertrichosis) in some individuals.[1] Other signs and symptoms may include seizures, headaches, diabetes insipidus, and sex gland disturbances.[2] The cause of Morgagni-Stewart-Morel syndrome is not fully understood. Some instances of dominant inheritance have been reported, but whether it is autosomal dominant or X-linked dominant is not known.[3]
Last updated: 3/25/2011

What are the signs and symptoms of Morgagni-Stewart-Morel syndrome?

The signs and symptoms of Morgagni-Stewart-Morel (MSM) syndrome typically include the characteristic X-ray finding of thickening of the frontal bone of the skull (hyperostosis frontalis interna) and may also include headache, vertigo, hirsutism, menstrual disorders, galactorrhea, obesity, depression, irritability, fatigability, temporary paralysis on one side of the body, hearing impairment, paralysis of the cranial nerves, muscle weakness, and seizures.[4]
Last updated: 3/28/2011

How might Morgagni-Stewart-Morel syndrome be diagnosed?

The diagnosis of Morgagni-Stewart-Morel syndrome is based upon a radiological finding of hyperostosis frontalis interna, as well as a combination of clinical features including obesity, virulism, possible mental disturbance, and other findings.[5][6]
Last updated: 3/25/2011

Is Morgagni-Stewart-Morel syndrome associated with other conditions?

Morgagni-Stewart-Morel syndrome is commonly associated with diabetes mellitus, diabetes insipidus, or hyperparathyroidism.[4]
Last updated: 7/17/2013

Is hyperostosis frontalis interna always associated with Morgagni-Stewart-Morel syndrome?

While people with Morgagni-Stewart-Morel syndrome nearly always have hyperostosis frontalis interna, hyperostosis frontalis interna is usually an incidental finding on x-ray films, computed tomography, or magnetic resonance imaging of the head and by itself is not indicative of any disease.[6]
Last updated: 7/17/2013

Who is most commonly diagnosed with Morgagni-Stewart-Morel syndrome?

Morgagni-Stewart-Morelsyndrome is most commonly diagnosed in females.[5] Hyperostosis frontalis interna, a major symptom of Morgagni-Stewart-Morel syndrome, is more common in elderly patients and postmenopausal women, especially when associated with obesity.[6]
Last updated: 7/17/2013

What causes Morgagni-Stewart-Morel syndrome?

The cause of Morgagni-Stewart-Morel syndrome and hyperostosis frontalis interna is unknown.
Last updated: 3/25/2011

Is Morgagni-Stewart-Morel syndrome genetic?

The role genes play in the development of Morgagni-Stewart-Morel syndrome is still unclear. There have been a few case reports describing multiple members of the same family with Morgagni-Steward-Morel syndrome and in these families the syndrome appears to be inherited in a autosomal dominant or X-linked dominant fashion.[5]
Last updated: 7/17/2013

References
Other Names for this Disease
  • Hyperostosis frontalis interna, obesity, shortness and cognitive impairment
  • MSM syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.