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Genetic and Rare Diseases Information Center (GARD)

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Morgagni-Stewart-Morel syndrome

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Other Names for this Disease

  • Hyperostosis frontalis interna, obesity, shortness and cognitive impairment
  • MSM syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

What is Morgagni-Stewart-Morel syndrome?

What are the signs and symptoms of Morgagni-Stewart-Morel syndrome?

What causes Morgagni-Stewart-Morel syndrome?

What is Morgagni-Stewart-Morel syndrome?

Morgagni-Stewart-Morel (MSM) syndrome is a condition characterized by thickening of the frontal bone of the skull (hyperostosis frontalis interna), as well as obesity and excessive hair growth (hypertrichosis) in some individuals.[1] Other signs and symptoms may include seizures, headaches, diabetes insipidus, and sex gland disturbances.[2] The cause of Morgagni-Stewart-Morel syndrome is not fully understood. Some instances of dominant inheritance have been reported, but whether it is autosomal dominant or X-linked dominant is not known.[3]
Last updated: 3/25/2011

What are the signs and symptoms of Morgagni-Stewart-Morel syndrome?

The signs and symptoms of Morgagni-Stewart-Morel (MSM) syndrome typically include the characteristic X-ray finding of thickening of the frontal bone of the skull (hyperostosis frontalis interna) and may also include headache, vertigo, hirsutism, menstrual disorders, galactorrhea, obesity, depression, irritability, fatigability, temporary paralysis on one side of the body, hearing impairment, paralysis of the cranial nerves, muscle weakness, and seizures.[4]
Last updated: 3/28/2011

What causes Morgagni-Stewart-Morel syndrome?

The cause of Morgagni-Stewart-Morel syndrome and hyperostosis frontalis interna is unknown.
Last updated: 3/25/2011

References
  1. Morgagni-Stewart-Morel syndrome. Orphanet. June 2006; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=77296. Accessed 3/25/2011.
  2. Hyperostosis Frontalis Interna. NORD. 2007; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Hyperostosis%20Frontalis%20Interna. Accessed 3/25/2011.
  3. Victor A. McKusick et al. HYPEROSTOSIS FRONTALIS INTERNA. OMIM. 1986-2009; http://www.ncbi.nlm.nih.gov/omim/144800. Accessed 3/25/2011.
  4. Nallegowda M, Singh U, Khanna M, Yadav SL, Choudhary AR, Thakar A . Morgagni Stewart morel syndrome-Additional features. Neurology India. 2005; http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2005;volume=53;issue=1;spage=117;epage=119;aulast=Nallegowda. Accessed 2/28/2008.


Other Names for this Disease
  • Hyperostosis frontalis interna, obesity, shortness and cognitive impairment
  • MSM syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.